![Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer | Oncogene Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer | Oncogene](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41388-020-1383-4/MediaObjects/41388_2020_1383_Fig1_HTML.png)
Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer | Oncogene
![ATR Target Activation by the CHK1 Inhibitor AZD7762 in U2OS Cancer Cells | Download Scientific Diagram ATR Target Activation by the CHK1 Inhibitor AZD7762 in U2OS Cancer Cells | Download Scientific Diagram](https://www.researchgate.net/profile/Martin_Scobie/publication/289970074/figure/fig2/AS:316872802226177@1452559772322/ATR-Target-Activation-by-the-CHK1-Inhibitor-AZD7762-in-U2OS-Cancer-Cells.png)
ATR Target Activation by the CHK1 Inhibitor AZD7762 in U2OS Cancer Cells | Download Scientific Diagram
![5 (3 Fluorophenyl) N (3 Piperidinyl) 3 Ureido 2 Thiophenecarboxamide - an overview | ScienceDirect Topics 5 (3 Fluorophenyl) N (3 Piperidinyl) 3 Ureido 2 Thiophenecarboxamide - an overview | ScienceDirect Topics](https://ars.els-cdn.com/content/image/3-s2.0-B9780128122068000133-f13-02-9780128122068.jpg)
5 (3 Fluorophenyl) N (3 Piperidinyl) 3 Ureido 2 Thiophenecarboxamide - an overview | ScienceDirect Topics
![Effect of AR Knockdown and Chk1/2 Inhibitor AZD7762 on TopBP1-ATR-Chk1... | Download Scientific Diagram Effect of AR Knockdown and Chk1/2 Inhibitor AZD7762 on TopBP1-ATR-Chk1... | Download Scientific Diagram](https://www.researchgate.net/publication/314254302/figure/fig2/AS:613929935990786@1523383711028/Effect-of-AR-Knockdown-and-Chk1-2-Inhibitor-AZD7762-on-TopBP1-ATR-Chk1-Signaling-and-PCa.png)
Effect of AR Knockdown and Chk1/2 Inhibitor AZD7762 on TopBP1-ATR-Chk1... | Download Scientific Diagram
![Combination Treatment of VE-821 and AZD7762 Results in S Phase Arrest... | Download Scientific Diagram Combination Treatment of VE-821 and AZD7762 Results in S Phase Arrest... | Download Scientific Diagram](https://www.researchgate.net/profile/Martin_Scobie/publication/289970074/figure/fig9/AS:669630435704834@1536663745089/Combination-Treatment-of-VE-821-and-AZD7762-Results-in-S-Phase-Arrest-in-U2OS-Cells-A.png)
Combination Treatment of VE-821 and AZD7762 Results in S Phase Arrest... | Download Scientific Diagram
Discovery of Checkpoint Kinase Inhibitor (S)-5-(3-Fluorophenyl)-N-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide ( AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas | Journal of Medicinal Chemistry
![Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine | Journal of Experimental & Clinical Cancer Research | Full Text Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0473-1/MediaObjects/13046_2016_473_Fig6_HTML.gif)
Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine | Journal of Experimental & Clinical Cancer Research | Full Text
![Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. - Abstract - Europe PMC Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. - Abstract - Europe PMC](https://europepmc.org/articles/PMC2889008/bin/nihms201260f2.jpg)
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. - Abstract - Europe PMC
![IJMS | Free Full-Text | Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development | HTML IJMS | Free Full-Text | Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development | HTML](https://www.mdpi.com/ijms/ijms-21-07878/article_deploy/html/images/ijms-21-07878-g005.png)
IJMS | Free Full-Text | Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development | HTML
![Cells | Free Full-Text | DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives | HTML Cells | Free Full-Text | DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives | HTML](https://www.mdpi.com/cells/cells-11-01463/article_deploy/html/images/cells-11-01463-g001.png)
Cells | Free Full-Text | DNA Damage Response Inhibitors in Cholangiocarcinoma: Current Progress and Perspectives | HTML
![Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. - Abstract - Europe PMC Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. - Abstract - Europe PMC](https://europepmc.org/articles/PMC2889008/bin/nihms201260f1.jpg)
Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. - Abstract - Europe PMC
![The Chk1/2 inhibitor AZD7762 sensitizes SW480 colon cancer cells to... | Download Scientific Diagram The Chk1/2 inhibitor AZD7762 sensitizes SW480 colon cancer cells to... | Download Scientific Diagram](https://www.researchgate.net/profile/Mariana-Brocardo-2/publication/266744066/figure/fig2/AS:295754355757078@1447524741768/The-Chk1-2-inhibitor-AZD7762-sensitizes-SW480-colon-cancer-cells-to-5-FU-A-SW480-cells_Q320.jpg)
The Chk1/2 inhibitor AZD7762 sensitizes SW480 colon cancer cells to... | Download Scientific Diagram
![Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine | Journal of Experimental & Clinical Cancer Research | Full Text Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine | Journal of Experimental & Clinical Cancer Research | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13046-016-0473-1/MediaObjects/13046_2016_473_Fig2_HTML.gif)
Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine | Journal of Experimental & Clinical Cancer Research | Full Text
![Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro - Wang - 2018 - Cancer Medicine - Wiley Online Library Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro - Wang - 2018 - Cancer Medicine - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/fc682e1c-34eb-4251-9ba6-4940458c93b2/cam41638-toc-0001-m.jpg)
Evaluation of CHK1 activation in vulvar squamous cell carcinoma and its potential as a therapeutic target in vitro - Wang - 2018 - Cancer Medicine - Wiley Online Library
![Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours | SpringerLink Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00280-013-2234-6/MediaObjects/280_2013_2234_Fig1_HTML.gif)
Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours | SpringerLink
![Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours | SpringerLink Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours | SpringerLink](https://media.springernature.com/lw685/springer-static/image/art%3A10.1007%2Fs00280-013-2234-6/MediaObjects/280_2013_2234_Fig2_HTML.gif)